Background: Hyperlipidaemia may be a potential risk factor for the occurrence of intestinal polyps. This study\naimed to evaluate correlation between lipidaemia and the formation of colorectal polyps.\nMethods: One hundred and fourteen patients with colorectal polyps and forty-eight healthy controls were included in\nthis study. Colonoscopies were performed for all patients and controls within 1 week before blood samples were taken.\nThe concentrations of serum lipids and lipoproteins were measured simultaneously using an automatic biochemical\nanalyser. The colorectal lesions were classified based on pathological characteristics, and four types were identified in\nthe study: hyperplastic polyp (HP), tubular adenoma (TA), tubulovillous adenoma (TVA) and adenoma with high-grade\ndysplasia (A-HGD). Advanced adenoma was classified according to the number, size and histological type of polyps.\nResults: The value of low-density lipoprotein cholesterol (LDL-C) was significantly higher in the group with advanced\nadenoma than in the controls (p < 0.05). Moreover, the LDL-C values in the HP and TA groups were higher when\ncompared to that of controls (p < 0.05). Obesity, age, and increased TG and LDL-C were independent risk factors for the\nformation of colorectal polyps. The cut-off values of triglyceride (TG) and LDL-C to distinguish polyp patients from\nhealthy controls were 0.96mmol/L (AUC = 0.604, p = 0.036) and 3.05mmol/L (AUC = 0.654, p = 0.002). The combined\nuse of increased LDL-C and TG levels to distinguish polyp patients was effective, with a sensitivity of 50.0% and a\nspecificity of 89.6% (AUC = 0.733, p < 0.01).\nConclusions: Colorectal polyps are more often found in obese and older patients. Increased LDL-C and TG were\ncorrelated with the occurrence of polyps. Combination of the two serum indicators was useful to assess risk of\ncolorectal lesions, maybe more effective in screening hyperplastic polyp, tubular adenoma and advanced adenoma.
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